Cardiomyocyte maturation alters molecular stress response capacities and determines cell survival upon mitochondrial dysfunction

In conclusion, our results identified fundamental differences in cell survival and stress response in differentiated compared to immature cardiomyocytes subjected to mitochondrial dysfunction. The high stress tolerance of immature cardiomyocytes might allow outlasting unfavorable intrauterine conditions thereby preventing fetal or perinatal heart disease and may contribute to the regenerative capacity of the embryonic and neonatal mammalian heart.PMID:38266827 | DOI:10.1016/j.freeradbiomed.2024.01.034
Source: Free Radical Biology and Medicine - Category: Biology Authors: Source Type: research