Intestinal mRNA expression analysis of polarity ‐related genes identified the discriminatory ability of CRB3 as a diagnostic marker for celiac disease

ConclusionThe aim of the current study was to evaluate the changes in the mRNA expression levels ofSCRIB,PRKCZ,LKB1, andCRB3 genes in the small intestinal biopsy samples of CD patients in comparison to the healthy control subjects. Our data uncover the importance of polarity-related genes (especiallyCRB3) in CD pahtomechanism, that may facilitate the planning of the future studies looking for finding innovative diagnostic and therapeutic strategies for CD.

Source: Immunity, Inflammation and Disease - February 14, 2024 Category: Allergy & Immunology Authors: Tannaz Taraz, Nastaran Asri, Ehsan Nazemalhosseini ‐Mojarad, Flora Forouzesh, Mostafa Rezaei‐Tavirani, Mohammad Rostami‐Nejad Tags: ORIGINAL ARTICLE Source Type: research