Tumor volume and cancer stem cell expression as prognostic markers for high-dose loco-regional failure in head and neck squamous cell carcinoma – a DAHANCA 19 study

Following primary radiotherapy (RT), the outcome for patients with head and neck squamous cell carcinoma (HNSCC) has improved over the last decades [1]. This may partly be explained by the increasing frequency of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) [2], and partly by intensified treatment regimens including technical and biological optimization. In Denmark, loco-regional control has improved with the addition of hypoxic sensitization (nimorazole) [3], reduced overall treatment time (6 fractions/week), and concomitant chemotherapy, adjusted for the influence of stage and HPV-status [1].

Source: Radiotherapy and Oncology - February 8, 2024 Category: Radiology Authors: Morten Horsholt Kristensen, Mia Kristina S ørensen, Trine Tramm, Jan Alsner, Brita Singers Sørensen, Christian Maare, Jørgen Johansen, Hanne Primdahl, Åse Bratland, Claus Andrup Kristensen, Maria Andersen, Jacob Kinggaard Lilja-Fischer, Anne Ivalu Sa Tags: Original Article Source Type: research