Circulating mitochondria promoted endothelial cGAS-derived neuroinflammation in subfornical organ to aggravate sympathetic overdrive in heart failure mice

Sympathoexcitation contributes to myocardial remodeling in heart failure (HF). Increased circulating pro-inflammatory mediators directly act on the Subfornical organ (SFO), the cardiovascular autonomic center,...

Source: Journal of Neuroinflammation - January 19, 2024 Category: Neurology Authors: Shutian Zhang, Dajun Zhao, Zhaohua Yang, Fanshun Wang, Shouguo Yang and Chunsheng Wang Tags: Research Source Type: research