Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1 α

Conclusions/interpretationOur results demonstrate an essential role for TET3 in the regulation of skeletal muscle insulin sensitivity and suggest that TET3 may be used as a potential therapeutic target for the metabolic syndrome.Data availabilitySequences are available from the Gene Expression Omnibus (https://www.ncbi.nlm.nih.gov/geo/) with accession number of GSE224042.Graphical Abstract
Source: Diabetologia - Category: Endocrinology Source Type: research