JOSD2 mediates isoprenaline-induced heart failure by deubiquitinating CaMKII δ in cardiomyocytes

In conclusion, our study highlights the role of JOSD2 in mediating ISO-induced cardiac remodeling through the regulation of CaMKIIδ ubiquitination, and suggests its potential as a therapeutic target for combating the disease. Please check and confirm that the authors and their respective affiliations have been correctly identified and amend if necessary. All have been checked.PMID:38195959 | DOI:10.1007/s00018-023-05037-7

Source: Cellular and Molecular Life Sciences : CMLS - January 10, 2024 Category: Cytology Authors: Jiachen Xu Shiqi Liang Qinyan Wang Qingsong Zheng Mengyang Wang Jinfu Qian Tianxiang Yu Shuaijie Lou Wu Luo Hao Zhou Guang Liang Source Type: research