Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes

In conclusion, Quer targets SLC1A5 in GC cells, inhibiting the NRF2/xCT pathway, activating the p-Camk2/p-DRP1 pathway, and accelerating iron deposition. Ultimately, Quer promotes ferroptosis in GC cells, inhibiting GC progression. Overall, our study reveals that Quer can potentially impede GC progression by targeting SLC1A5, offering novel therapeutic avenues through the modulation of ferroptosis and iron homeostasis.PMID:38190923 | DOI:10.1016/j.freeradbiomed.2024.01.002

Source: Free Radical Biology and Medicine - January 8, 2024 Category: Biology Authors: Lixian Ding Shuwei Dang Mingjun Sun Dazhi Zhou Yanyan Sun Encheng Li Shuqi Peng Jinxing Li Guodong Li Source Type: research