Riluzole Mitigates The Risk Of Heart Failure Admissions

Targeting intracellular sodium accumulation through the late Na+ current modulates cardiac calcium handling, which underlies myocardial contractility and relaxation in heart failure (HF). This modulation has been recognized as a potential new early strategy in maintaining neurohormonal balance to evade acute heart failure (AHF). Riluzole (R) is an agent for management of amyotrophic lateral sclerosis (ALS). It promotes neuronal-type Na+ channel blockade and enhances Ca2+-activated K+ channel function.

https://onlinejcf.com/article/S1071-9164(23)00492-X/fulltext?rss=yes

Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Kibum Kim, Sodam Kim, Margaret Katana, Przemyslaw Radwanski, Mark A. Munger Tags: 105 Source Type: research