Canagliflozin attenuates kidney injury, gut-derived toxins, and gut microbiota imbalance in high-salt diet-fed Dahl salt-sensitive rats

CONCLUSION: Canagliflozin may change the production of metabolites and reduce the level of uremic toxins in the blood circulation by reconstructing the intestinal flora of DSS rats fed a high-salt diet, ultimately alleviating oxidative stress and renal injury.PMID:38189082 | DOI:10.1080/0886022X.2023.2300314

Source: Renal Failure - January 8, 2024 Category: Urology & Nephrology Authors: Lili He Qingjuan Zuo Sai Ma Guorui Zhang Zhongli Wang Tingting Zhang Jianlong Zhai Yifang Guo Source Type: research