Trimethylamine N-oxide promotes abdominal aortic aneurysm by inducing vascular inflammation and vascular smooth muscle cell phenotypic switching

CONCLUSIONS: TMAO promotes AAA formation by inducing vascular inflammation and VSMC phenotypic switching through activation of the NF-κB signaling pathway. Thus, TMAO is a prospective therapeutic AAA target.PMID:38160930 | DOI:10.1016/j.ejphar.2023.176307

Source: European Journal of Pharmacology - December 31, 2023 Category: Drugs & Pharmacology Authors: Bo Wei Na Deng Haijun Guo Yingying Wei Fujia Xu Sihan Luo Weili You Jingjing Chen Wei Li Xiaoyun Si Source Type: research