Evaluating the Protective Effects of Melatonin Against Chronic Iron Administration in Male Wistar Rats: a Comparative Analysis of Affective, Cognitive, and Oxidative Stress with EDTA Chelator

In this study, we performed a neurobehavioral assessment and biochemical determinations of oxidative stress levels in the hippocampus and prefrontal cortex of each animal. The results indicate that chronic exposure to iron sulfate induced anxiety-like depressive behavior, and cognitive impairment also increased the levels of lipid peroxidation and nitric oxide, and reduced the activity of catalase in the hippocampus and prefrontal cortex in male Wistar rats, suggesting the induction of oxidative stress. In contrast, these alterations were reversed by melatonin better than EDTA. The results of this study show that melatonin protects against the neurobehavioral changes caused by iron, which may be associated with decreasing oxidative stress in the hippocampus and prefrontal cortex.PMID:38146034 | DOI:10.1007/s12011-023-04006-2

Source: Biological Trace Element Research - December 25, 2023 Category: Biology Authors: Ayoub Rezqaoui Soufiane Boumlah Aboubaker El Hessni Mohamed Yassine El Brouzi Abdelghafour El Hamzaoui Laila Ibouzine-Dine Samir Benkirane Manal Adnani Abdelhalem Mesfioui Source Type: research