Action Mechanisms of Metformin Combined with Exenatide and Metformin Only in the Treatment of PCOS in Obese Patients

CONCLUSION: Compared with metformin alone in the treatment of PCOS, the differential metabolites of the exenatide combined with metformin group are more extensive. The COM group may act on the hypothalamic-pituitary-gonadal axis (HPO) and its bypass, regulate multiple metabolism pathways such as phospholipids, amino acids, fatty acids, carnitine, bile acids, and glucose directly or indirectly in obese PCOS patients.PMID:38131036 | PMC:PMC10735721 | DOI:10.1155/2023/4288004

Source: International Journal of Endocrinology - December 22, 2023 Category: Endocrinology Authors: Jingwen Gan Jie Chen Rui-Lin Ma Yan Deng Xue-Song Ding Shi-Yang Zhu Ai-Jun Sun Source Type: research