Age-Induced Accumulation of Succinate Promotes Cardiac Fibrogenesis

CONCLUSIONS: Our findings indicate that targeting metabolic dysregulation has significant implications for the treatment of age-related cardiac fibrosis and diastolic dysfunction. We further demonstrate a novel mechanism by which succinate induces fibroblast activation and apoptosis resistance by promoting PKM2 dimerization. Hence, inhibiting succinate generation or blocking its downstream effects is potentially a promising new strategy for slowing the heart aging.PMID:38112098 | DOI:10.1161/CIRCRESAHA.123.323651

Source: Circulation Research - December 19, 2023 Category: Cardiology Authors: Ziwen Wang Shu Yang Zheng Ping Yaqi Li Ting Jiang Xin Zheng Ziyuan Zhang Guan Wang Zhaochuan Liu Haimei Sun Qi Zhang Heyang Zhang Yang Gao Youxin Feng Xixi Liu Lizhuang Han Shiqi Lin Xiaowei Zhang Mengmeng Song Tong Liu Meng Tang Chenan Liu Hailun Xie Guo Source Type: research