Live Birth After Uterus Transplantation

This report describes the first live birth in a woman with absolute uterine infertility who became pregnant following a uterine transplant from a live donor. The mother was a 35-year-old woman with Rokitansky syndrome who underwent transplantation of the uterus in 2013 at Sahlgrenska University Hospital, Gothenburg, Sweden. The donor was a family friend, a 61-year-old, 2-parous woman with 2 previous vaginal deliveries. The recipient and her partner underwent in vitro fertilization prior to the transplant, and 11 embryos were cryopreserved. Following the transplant, both the recipient and the donor had essentially uneventful postoperative recoveries. The first menstruation in the recipient occurred 43 days after transplantation, and thereafter, she menstruated regularly every 26 to 36 days (median, 32 days). One year after the womb transplant, the first single embryo transfer was performed and resulted in pregnancy. She then began taking triple immunosuppression medications (tacrolimus, azathioprine, and corticosteroids), which was continued for the remainder of the pregnancy. Three episodes of mild rejection occurred, one of which occurred during pregnancy; all were reversed by corticosteroid treatment. Blood flows of the uterine arteries and umbilical cord as well as fetal growth parameters were normal throughout pregnancy. At 31 weeks 5 days’ gestation, the patient was admitted to the hospital with preeclampsia. Because the baby's heart rate was abnormal, a cesarean deliv...
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: Gynecology: Infertility/Reproductive Technologies Source Type: research