Body Mass Index and Clinical and Health Status Outcomes in Chronic Coronary Disease and Advanced Kidney Disease in the ISCHEMIA-CKD Trial

Although overweight and obesity are associated with greater mortality and cardiovascular morbidity in patients without known cardiovascular disease, a paradoxical relationship between body mass index (BMI) and clinical outcomes has been observed in patients with cardiovascular disease.1-4 For example, the INternational VErapamil SR-Trandolapril STudy demonstrated that participants with chronic coronary disease and hypertension with class I obesity (BMI 30 to 35 kg/m2) had a lower risk for all-cause mortality, non-fatal myocardial infarction, or non-fatal stroke than those with normal BMI (20 to 25 kg/m2).

Source: The American Journal of Medicine - November 2, 2023 Category: General Medicine Authors: Roy O. Mathew, Evgeny I. Kretov, Zhen Huang, Philip G. Jones, Mandeep S. Sidhu, Sean M. O'Brien, Aleksei A. Prokhorikhin, Janani Rangaswami, Jonathan Newman, Gregg W. Stone, Jerome L. Fleg, John A. Spertus, David J. Maron, Judith S. Hochman, Sripal Bangal Tags: Clinical Research Study Source Type: research