Specific Inhibition of Orai1-mediated Calcium Signalling Resolves Inflammation and Clears Bacteria in an ARDS Model

Conclusions: These data indicate that specific Orai1 inhibition by ELD607 may be a novel approach to reduce multi-organ inflammation and treat antibiotic-resistant bacteria.PMID:37972349 | DOI:10.1164/rccm.202308-1393OC

Source: Respiratory Care - November 16, 2023 Category: Respiratory Medicine Authors: Saira Ahmad Joe A Wrennall Alexandra S Goriounova Malika Sekhri Jason A Iskarpatyoti Arunava Ghosh Sabri H Abdelwahab Alexis Voeller Mani Rai Rahul Y Mahida Krzysztof Krajewski Diane M Ignar Alon Greenbaum Timothy P Moran Stephen L Tilley David R Thickett Source Type: research