Mendelian randomization studies in atopic dermatitis: a systematic review

Prior studies have found associations between atopic dermatitis (AD) and comorbidities including depression, obesity, asthma, and allergic rhinitis. While observational studies often cannot establish robust causality between potential risk factors and AD, Mendelian randomization (MR) minimizes confounding when exploring causality by relying on random allelic assortment at birth. Here, we systematically reviewed 30 MR studies in AD. Body mass index, gut microbial flora, the IL18 signaling pathway, and gastroesophageal reflux disease were among causal factors for AD, while AD was causal for several medical conditions including heart failure, rheumatoid arthritis, and conjunctivitis.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research