BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK-1/Egr-1 axis

CONCLUSIONS: Our findings suggest that BAML1 can target the ERK1/2/ELK-1/Egr-1 axis to suppress fibrotic progression and inflammatory events in obstructed kidneys, thereby inhibiting the development of CKD.PMID:37951191 | DOI:10.1016/j.intimp.2023.111140

Source: International Immunopharmacology - November 11, 2023 Category: Allergy & Immunology Authors: Wu Chen Sheng Zhao Ji Xing Weimin Yu Ting Rao Xiangjun Zhou Yuan Ruan Siqi Li Yuqi Xia Tianbao Song Fan Zou Wei Li Fan Cheng Source Type: research