Long non-coding RNA PVT1 is overexpressed in cutaneous squamous cell carcinoma and exon 2 is critical for its oncogenicity

CONCLUSIONS: Our study reveals a previously unrecognized role for exon 2 of PVT1 in its oncogenic role and that PVT1 suppresses cellular senescence in cSCC. PVT1 may be a biomarker and therapeutic target in cSCC.PMID:37930852 | DOI:10.1093/bjd/ljad419

Source: The British Journal of Dermatology - November 6, 2023 Category: Dermatology Authors: Chen Li Chengxi Sun Kunal Das Mahapatra Pilvi Riihil ä Jaakko Knuutila Liisa Nissinen Jan Lapins Veli-Matti K ähäri Bernhard Homey Enik ö Sonkoly Andor Pivarcsi Source Type: research