Lipotoxicity-polarised macrophage-derived exosomes regulate mitochondrial fitness through Miro1-mediated mitophagy inhibition and contribute to type 2 diabetes development in mice

Conclusions/interpretationThese findings suggest that the miR-27-3p –Miro1 axis, as a novel regulatory mechanism for mitophagy, could be considered as a new therapeutic target for lipotoxicity-related type 2 diabetes disease development.Graphical Abstract
Source: Diabetologia - Category: Endocrinology Source Type: research