A Comprehensive Investigation of Risk Association Between the -786  T  & gt;  C, + 884 G  & gt;  A, VNTR, rs743506, rs3918226 of eNOS and Susceptibility of Migraine: A Updated Meta-Analysis Utilizing Trial Sequential Analysis

AbstractWith a feature of complex pathogenic mechanisms, migraine is a well-known common neurovascular disorder. Multiple genes are responsible for hindering the susceptibility of pain threshold one of which is theeNOS gene and its variants. Multiple independent observational studies with case –control design produced conflicting findings, which can be attributed to a variety of factors including varying sample sizes, demographic stratification, technique application, etc. Therefore, in the present study we aimed to find out the precise risk between the selected variant ofeNOS and the risk of migraine and its clinical subtypes using a meta-analysis approach. To find the association between the risk variants of theeNOS gene and migraine, a PRISMA-based systematic literature review strategy was utilized to search via online resources including PubMed and Google Scholar. Using several genetic models, odds ratios with 95% confidence intervals were computed to pool the data. To access heterogeneity, Cochran's Q Test and I2 statistics were utilized, while Begg's and Egger's tests were used to determine publication bias. A p-value of 0.05 or below was deemed statistically significant for all two-sided tests. The present meta-analysis was able to find out the significant protective association between rs743506 and migraine after using dominant (OR: 0.66, CI [0.49 –0.86]), over-dominant (OR: 0.56, CI [0.42–0.75]), codominant model (OR: 0.58, CI[0.43–0.77]). Only significant ri...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research