Death of children with Down syndrome by gestational age and cause

CONCLUSIONS: These data on the high mortality and morbidity of preterm infants with DS may be useful for patient treatment and parent counseling in NICUs treating critically ill infants.IMPACT: Most infants with Down syndrome born at <34 weeks' gestation are born by cesarean section because of the non-reassuring fetal status. The mortality rate before discharge for infants with Down syndrome born at <34 weeks' gestation was 40%, and 30% of survivors developed moderate or severe cerebral palsy. The risk of death due to bronchopulmonary dysplasia and pulmonary hypertension was high in very preterm infants with Down syndrome despite the absence of chorioamnionitis. Infants with Down syndrome were born 1-2 weeks earlier than unaffected controls.PMID:37898703 | DOI:10.1038/s41390-023-02870-1

Source: Pediatric Research - October 29, 2023 Category: Pediatrics Authors: Tomoyuki Shimokaze Katsuaki Toyoshima Tomoko Saito Kaoru Katsumata Takahiro Kemmotsu Hiroshi Ishikawa Kenji Kurosawa Source Type: research