Late Breaking Abstract - Investigation of cKIT driven bone marrow toxicity and translation to human

In conclusion, identifying cKIT as an off-target, combining the PK/PD understanding of rat iTOX data and the MPS-based mathematical modelling of clinical haematotoxicity provided confidence to progress the compound into clinical development and informed the Ph1 study design.

Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Larsson, M., Gill, S., Pin, C., Pachl, F., Khan, K., Cartwright, J., Macdonald, R., Rose, J., Clayton, B., Leonard, E., Hornberg, J., Ollerstam, A., Larner, C. Tags: Mechanisms of lung injury and repair Source Type: research