The investigation of antidepressant and anxiolytic effects of pregabalin and its mechanisms of action in rats

CONCLUSION: PGB had a depressant effect in all doses and a dose-dependently anxiolytic effect. In combinations of PGB with AMT, KET, and DZM, it reversed their antidepressant effects. We assumed FLX could be preferred instead of AMT in patients using PGB. When PGB is used in combination, drug interactions should be considered. These results are also very remarkable in terms of pharmacoeconomics.PMID:37886867 | DOI:10.14744/agri.2022.98474

Source: Agri Dergisi - October 27, 2023 Category: Anesthesiology Authors: Şule Aydın Cansu K ılıç Tatlıcı Mustafa Erhan Çivgin Zeynep G ül Yazıcı Cafer Y ıldırım Setenay Din çer Öner Fatma Sultan K ılıç Source Type: research