Increased iron utilization and oxidative stress tolerance in a < em > Vibrio cholerae flrA < /em > mutant confers resistance to amoeba predation

This study explores how a mutant of V. cholerae adapts to acquire essential nutrients and survive predation. Here, we observed that up-regulation of iron acquisition genes and genes regulating resistance to oxidative stress enhances pathogen fitness. Our data show that V. cholerae can defend predation to overcome nutrient limitation and oxidative stress, resulting in an enhanced survival inside the protozoan hosts.PMID:37882527 | DOI:10.1128/aem.01095-23

Source: Applied and Environmental Microbiology - October 26, 2023 Category: Microbiology Authors: M Mozammel Hoque Parisa Noorian Gustavo Espinoza-Vergara Srijon Adhikary Joyce To Scott A Rice Diane McDougald Source Type: research