Complex roles of Hippo-YAP/TAZ signaling in hepatocellular carcinoma

ConclusionThis review highlights the important roles of Yap/Taz in activating Hippo pathway in liver cancer. The  recent findings on the crosstalks between the Hippo and other cancer associated pathways and moleculars are also discussed.Graphical abstractIn this review, we summarized and discussed recent breakthroughs in our understanding of how key components of the Hippo-YAP/TAZ pathway influence the hepatocellular carcinoma, including their effects on tumor occurrence and development, their roles in regulating metastasis, and their function in chemotherapy resistance. Further, the molecular mechanism and roles in regulating cross talk between Hippo-YAP/TAZ pathway and other cancer-associated pathways or oncogenes/cancer suppressor genes were summarized and discussed. More, many other inducers and inhibitors of this signaling cascade and available experimental therapies against the YAP/TAZ/TEAD axis were discussed. Targeting this pathway for cancer therapy may have great significance in the treatment of hepatocellular carcinoma. Graphical summary of the complex role of Hippo-YAP/TAZ signaling in hepatocellular carcinoma
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research