Memory Reflections of the Microbiota-Gut and Oligodendrocyte Axis

CNS Neurol Disord Drug Targets. 2023 Oct 5. doi: 10.2174/0118715273256132230921103333. Online ahead of print.ABSTRACTMemory is the persisting consequence of cognitive activities instigated by and engrossed on exterior information from the environment and commenced by an intensive on internal mental representations. Establishing a gut-brain axis (GBA) in health and disease has recently brought the gut, the main portal of communication with the external environment, to the forefront of this interaction. Dietary stimuli have long been linked to brain development, behavioral responses, and memory reflections. Vagus nerve, immune system, bacterial metabolites and products are just a few of the linkages that make up the GBA, a bidirectional arrangement of signaling pathways that connects the neurological system with the gastrointestinal tract. GBA involves two-way communication between central and enteric neural systems, connecting the brain's affective and cognitive regions to peripheral activities of the intestine. Recent scientific progress has highlighted the significance of gut microbiota in affecting these relationships. By controlling myelination at the prefrontal cortex, a crucial area for multifaceted cognitive behavior forecast and decision-making, this axis influences social behavior, including memory reflections. Humans may experience late myelination of the prefrontal cortex's axonal projections into the third decade of life, making it vulnerable to outside factors lik...

Source: CNS and Neurological Disorders Drug Targets - October 19, 2023 Category: Drugs & Pharmacology Authors: Suman Kumar Ray Sukhes Mukherjee Source Type: research