Circulating microRNAs and cardiomyocyte proliferation in heart failure patients related to 10  years survival

ConclusionsThis study proposes that generating regenerative signals observed during PICSO intervention relate to patient outcomes. Morphogenetic pathways induced by periods of flow reversal in cardiac veins in a domino-like pattern transform embryonic into regenerative signals. Studies supporting the conversion of mechanochemical signals into regenerative molecules during PICSO are warranted to substantiate predictive power on patient longevity, opening new therapeutic avenues in otherwise untreatable heart failure.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Article Source Type: research