Preparation of poly(acrylic acid)/tricalcium phosphate nanoparticles scaffold: Characterization and releasing UC-MSCs derived exosomes for bone differentiation

CONCLUSION: The current research is the first study fabricating a multiscale scaffold using triCaPNPs in the substrate of PPA polymer using a cross-linker and freeze-drying process. This scaffold could mimic the nanoscale structure and chemical combination of native bone minerals. In addition, our results suggest that the PAA/triCaPNPs scaffold could be beneficial to achieve controlled exosome release for exosome-based therapy in bone tissue engineering.PMID:37736343 | PMC:PMC10509736 | DOI:10.34172/bi.2022.24142

Source: BioImpacts - September 22, 2023 Category: Research Authors: Nahid Moradi Saeid Kaviani Mina Soufizomorrod Simzar Hosseinzadeh Masoud Soleimani Source Type: research