The effect of exercise on vascular health in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials

Am J Physiol Renal Physiol. 2023 Sep 21. doi: 10.1152/ajprenal.00152.2023. Online ahead of print.ABSTRACTPatients with chronic kidney disease (CKD) are at increased risk of cardiovascular disease. This increased risk cannot be fully explained by traditional risk factors such as hypertension. Endothelial dysfunction and arterial stiffness have been suggested as factors which explain some of the increased risk, and are independently associated with important cardiovascular outcomes in CKD patients. Studies in other disease populations have shown positive effects of exercise on vascular dysfunction. The aim of this review was to determine whether exercise training interventions improve measures of vascular function and morphology in patients across the spectrum of CKD and which exercise training interventions are most efficacious. A systematic search of Medline, Embase and the Cochrane Central Register identified 25 randomized, controlled trials. Only randomized control trials using an exercise intervention with non-exercising control group, and at least one measure of vascular function or morphology were included. Participants were non-dialysis CKD or transplant patients, or those requiring dialysis therapy. A systematic review was conducted according to PRISMA guidelines. A meta-analysis was completed for pulse wave velocity, augmentation index and measures of endothelial-dependent vasodilation. Data from 25 studies with 872 participants showed that exercise training reduced p...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Source Type: research