Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors (FH-A11KRASG12V-TCR) in Treating Patients With Metastatic Pancreatic, Colorectal and Non-Small Cell Lung Cancers With KRAS G12V Mutations

Conditions:   Metastatic Colorectal Adenocarcinoma;   Metastatic Lung Non-Small Cell Carcinoma;   Metastatic Pancreatic Adenocarcinoma;   Stage IV Colorectal Cancer AJCC v8;   Stage IV Lung Cancer AJCC v8;   Stage IV Pancreatic Cancer AJCC v8 Interventions:   Drug: Bendamustine;   Procedure: Biopsy;   Procedure: Biospecimen Collection;   Procedure: Computed Tomography;   Drug: Cyclophosphamide;   Procedure: Echocardiography;   Drug: Fludarabine;   Procedure: Leukapheresis;   Procedure: Magnetic Resonance Imaging;   Procedure: M ultigated Acquisition Scan;   Procedure: Positron Emission Tomography;   Biological: T-cell Receptor-engineered T-cells Sponsors:   Fred Hutchinson Cancer Center;   Affini-T Therapeutics, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials