Molecular mechanism underlying epithelial ‐mesenchymal transformation and cisplatin resistance in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) frequently develops resistance to cisplatin chemotherapy, a challenge linked to the epithelial-mesenchymal transformation (EMT) process. Our review elucidates the molecular crosstalk between EMT and cisplatin resistance in ESCC, spotlighting signaling pathways such as FOXO1, PI3K/Akt, and Wnt. Our insights offer a foundation for innovative therapeutic interventions, potentially revolutionizing ESCC treatment. AbstractEsophageal cancer (EC) occupies the seventh spot of the most prevalent malignancy cancer ailments worldwide and the sixth leading cause of cancer-related death. Esophageal squamous cell carcinoma (ESCC) is also the most predominant histological subtype of EC, and cisplatin (DDP) is commonly used as a first-line chemotherapeutic drug for the late advanced stages of the disease. However, the emergence of drug resistance during clinical treatment possesses a significant challenge to the therapeutic success and patient outcomes. Collectively, the epithelial-mesenchymal transformation (EMT) is a process in which transcription factors are induced to regulate the expression of epithelial and stromal markers to promote the differentiation of epithelial cells into stromal cells. Recent studies have demonstrated a close association between EMT and chemotherapy resistance in tumor cells, with concrete evidence of reciprocal reinforcement. Therefore, in this review, we elucidate the molecular mechanism underlying ESCC, shed light on ...
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: REVIEW Source Type: research