Pleiotropic CACNA1C Variants and Neuronal Function in Psychosis

Thanks to the ongoing global efforts of genomics consortia, genome-wide association studies are increasingly providing common variant genetic data that may be integrated with other, extant multi-omics data.CACNA1C is a prime example of a genome-wide association studies discovery with possible leads to bedside. It has strong effects on neurodevelopment, it is targeted with calcium channel blockers (CCB), and there is ample evidence ofCACNA1C common variant association with schizophrenia and with several other major psychiatric disorders,1 –10 most notably bipolar disorder.
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research