Corticosteroid implants for chronic non-infectious uveitis

CONCLUSIONS: Our confidence is limited that local corticosteroid implants are superior to sham therapy or standard-of-care therapy in reducing the risk of uveitis recurrence. We demonstrated different effectiveness on BCVA relative to comparators in people with non-infectious uveitis. Nevertheless, the evidence suggests that these implants may increase the risk of cataract progression and IOP elevation, which will require interventions over time. To better understand the efficacy and safety profiles of corticosteroid implants, we need future trials that examine implants of different doses, used for different durations. The trials should measure core standard outcomes that are universally defined, and measured at comparable follow-up time points.PMID:37642198 | PMC:PMC10464657 | DOI:10.1002/14651858.CD010469.pub4
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Source Type: research