Molecules, Vol. 28, Pages 6332: Inhibition of Enzymes Involved in Neurodegenerative Disorders and A & beta;1 & ndash;40 Aggregation by Citrus limon Peel Polyphenol Extract

Molecules, Vol. 28, Pages 6332: Inhibition of Enzymes Involved in Neurodegenerative Disorders and Aβ1–40 Aggregation by Citrus limon Peel Polyphenol Extract Molecules doi: 10.3390/molecules28176332 Authors: Rosaria Arcone Antonio D’Errico Rosarita Nasso Rosario Rullo Annarita Poli Paola Di Donato Mariorosario Masullo Alzheimer’s (AD) and Parkinson’s diseases (PD) are multifactorial neurogenerative disorders of the Central Nervous System causing severe cognitive and motor deficits in elderly people. Because treatment of AD and PD by synthetic drugs alleviates the symptoms often inducing side effects, many studies have aimed to find neuroprotective properties of diet polyphenols, compounds known to act on different cell signaling pathways. In this article, we analyzed the effect of polyphenols obtained from the agro-food industry waste of Citrus limon peel (LPE) on key enzymes of cholinergic and aminergic neurotransmission, such as butyryl cholinesterase (BuChE) and monoamine oxidases (MAO)-A/B, on Aβ1–40 aggregation and on superoxide dismutase (SOD) 1/2 that affect oxidative stress. In our in vitro assays, LPE acts as an enzyme inhibitor on BuChE (IC50 ~ 73 µM), MAO-A/B (IC50 ~ 80 µM), SOD 1/2 (IC50 ~ 10–20 µM) and interferes with Aβ1–40 peptide aggregation (IC50...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research