Empagliflozin decreases ageing-associated arterial stiffnening and decreases vascular fibrosis under normoglycemic conditions

In conclusion, empagliflozin decreased arterial stiffness in aged mice, indicating that SGLT2 inhibition could be a valuable strategy in mitigating vascular ageing. Further research is warranted to unravel the underlying, possibly region-specific, mechanisms.PMID:37619798 | DOI:10.1016/j.vph.2023.107212

Source: Vascular Pharmacology - August 24, 2023 Category: Drugs & Pharmacology Authors: C édric H G Neutel Callan D Wesley Melissa Van Praet Celine Civati Lynn Roth Guido R Y De Meyer Wim Martinet Pieter-Jan Guns Source Type: research