Cardioprotection from a Silent Syndrome: Effect of Gilbert's Syndrome on Cardiovascular Disease in Patients with Familial Hypercholesteremia

Due to a liver defect in lipid metabolism, patients with inherited heterozygous familial hypercholesterolemia (FH) are especially at risk for atherosclerotic cardiovascular disease (ASCVD). This likelihood is due to the cumulative effect of high cholesterol which starts at a young age. Gilbert's Syndrome (GS) is a separate genetic liver disease that results in mildly increased serum unconjugated bilirubin which is postulated to be cardioprotective for ASCVD. Both GS and FH represent two separate genetic liver diseases, one beneficial and one a leading cause of morbidity and mortality.
Source: Journal of Clinical Lipidology - Category: Lipidology Authors: Tags: Genetic Disorders Source Type: research