Infections, Vaccinations, and Risk of Alzheimer's Disease (AD)/Dementia: Probable Involvement of Reactivated Herpes Simplex Virus Type 1

Adv Exp Med Biol. 2023;1423:279-280. doi: 10.1007/978-3-031-31978-5_28.ABSTRACTInfections are associated with cognitive decline and increased risk of AD/dementia (Sochocka M, Zwolinska K, Leszek J. Curr Neuropharmacol 15:996-1009, 2017; Ou YN, Zhu JX, Hou XH, Shen XN, Xu W, Dong Q, et al. J Alzheimers Dis 75:299-309, 2020; Sipilä PN, Heikkilä N, Lindbohm JV, Hakulinen C, Vahtera J, Elovainio M, et al. Lancet Infect Dis 21:1557-1567, 2021; Damiano RF, Guedes BF, de Rocca CC, de Padua Serafim A, Castro LHM, Munhoz CD, et al. Eur Arch Psychiatry Clin Neurosci 272:139-154, 2022), and some studies have shown that vaccinations, such as BCG, against a variety of infections decrease the risk. Several reports have described an association of varicella zoster virus (VZV) with AD, and in an epidemiological study, we found that shingles, a disease caused by VZV, conferred a small increased AD/dementia risk, while vaccination against the disease led to a greatly decreased risk - subsequently confirmed by others (Lophatananon A, Mekli K, Cant R, Burns A, Dobson C, Itzhaki R, Muir K, BMJ Open 11:e045871, 2021a; Lehrer S, Rheinstein PH. In Vivo 35:3271-3275, 2021; Scherrer JF, Salas J, Wiemken TL, Hoft DF, Jacobs C, Morley JE. PLoS One 16:e0257405, 2021).PMID:37525055 | DOI:10.1007/978-3-031-31978-5_28

Source: Herpes - July 31, 2023 Category: Infectious Diseases Authors: Ruth F Itzhaki Source Type: research