Postmenopausal Hormone Treatment Correlates with Increased Dementia Risk

We report a nationwide study on the association between menopausal hormone therapy and development of dementia. 5,589 incident cases of dementia and 55,890 age matched controls were identified between 2000 and 2018 from a population of all Danish women aged 50-60 years in 2000 with no history of dementia or contraindications for use of menopausal hormone therapy. Compared with people who had never used treatment, people who had received oestrogen-progestin therapy had an increased rate of all cause dementia (hazard ratio 1.24). Increasing durations of use yielded higher hazard ratios, ranging from 1.21 for one year or less of use to 1.74 for more than 12 years of use. Oestrogen-progestin therapy was positively associated with development of dementia for both continuous (hazard ratio 1.31) and cyclic (hazard ratio 1.24) regimens. Associations persisted in women who received treatment at the age 55 years or younger (hazard ratio 1.24). Findings persisted when restricted to late onset dementia (hazard ratio 1.21) and Alzheimer's disease (hazard ratio 1.22). Link: https://doi.org/10.1136/bmj-2022-072770
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