Reversal of dual epigenetic repression of non-canonical Wnt-5a normalises diabetic corneal epithelial wound healing and stem cells

CONCLUSIONS/INTERPRETATION: We provide the first account of epigenetic changes in diabetic corneas including dual inhibition of WNT5A by DNA methylation and miRNA action. Overall, Wnt-5a is a new corneal epithelial wound healing stimulator that can be targeted to improve wound healing and stem cells in the diabetic cornea.DATA AVAILABILITY: The DNA methylation dataset is available from the public GEO repository under accession no. GSE229328 ( https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE229328 ).PMID:37460827 | DOI:10.1007/s00125-023-05960-1

Source: Cancer Control - July 17, 2023 Category: Cancer & Oncology Authors: Ruchi Shah Tanya M Spektor Daniel J Weisenberger Hui Ding Rameshwar Patil Cynthia Amador Xue-Ying Song Steven T Chun Jake Inzalaco Sue Turjman Sean Ghiam Jiho Jeong-Kim Sasha Tolstoff Sabina V Yampolsky Onkar B Sawant Yaron S Rabinowitz Ezra Maguen Pedram Source Type: research