Trade-off Resiliencies, Competing Disease Risks, and Ageotypes Virtual Workshop (Day 1)

Age is the primary risk factor for most major medical conditions, such as cardiovascular diseases (CVD), cancer, diabetes, and neurodegenerative diseases. Aging, disease development, respectively resilience, are thus interconnected, but the molecular pathways and cellular mechanisms involved are not well understood. Deep multi-omics profiling appears to distinguish four molecular patterns of aging in individuals, “ ageotypes, ” that may be connected to competing risk of age-associated diseases. Recent research indicates that development of CVD or cancer are perhaps due to trade-offs between certain genes and processes, such as cell proliferation or senescence, as well as the different types of one ’ s resiliencies to the variety of stresses that accumulate with age. An example of an immune-mediated dichotomy between Cancer or CVD was illustrated by the recent discovery of trade-offs associated with Clonal hematopoiesis of indeterminate potential (CHIP) mutations that accumulate with age in white blood cells. While CHIP increases the risk of hematological cancers, it also doubles the risk of CVD which is more likely to be the cause of death in those affected (via heart attacks and strokes). Such examples could help highlight essential molecular pathways and processes that may act as switches during lifespan and could be potentially exploited for disease prevention, interception, and treatment of CVD and cancer. We are proposing to organize in collaboration with NCI and ...
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