Transcriptomic analysis reveals the regulatory mechanism underlying the indirubin-mediated amelioration of dextran sulfate sodium-induced colitis in mice

CONCLUSION: Apart from the well-documented NF-κB signalling pathway, IL-17A, and NLRP3-IL-1β, the suppression of haemoglobin-induced lipid peroxidation could be a previously unknown mechanism of IDR. Our study can help improve its application for UC treatment.PMID:37439220 | DOI:10.1080/13880209.2023.2233565

Source: Pharmaceutical Biology - July 13, 2023 Category: Drugs & Pharmacology Authors: Zhe Liu Jin-Ru Zhang Yong-Xiang Huang Xue-Ying Li Hai-Peng Zhu Rui-Yi Yang Song Chen Source Type: research