Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide; however, the underlying mechanisms remain poorly understood. FAM3D is a member of the FAM3 family; however, its role in hepatic glycolipid metabolism remains unknown. Serum FAM3D levels are positively correlated with fasting blood glucose levels in patients with diabetes. Hepatocytes express and secrete FAM3D, and its expression is increased in steatotic human and mouse livers. Hepatic FAM3D overexpression ameliorated hyperglycemia and steatosis in obese mice, whereas FAM3D-deficient mice exhibited exaggerated hyperglycemia and steatosis after high-fat diet (HFD)-feeding.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Yuntao Hu, Jing Li, Xin Li, Di Wang, Rui Xiang, Wenjun Liu, Song Hou, Qinghe Zhao, Xiaoxing Yu, Ming Xu, Dong Zhao, Tao Li, Yujing Chi, Jichun Yang Source Type: research