Mutational signatures of synchronous and metachronous brain metastases from lung adenocarcinoma

In conclusion, CSF liquid biopsies have a priority in detecting gene alteration. A comprehensive comparison of molecular profiling between SBM and MBM revealed the most frequently altered genes in both groups wereEGFR andTP53, but with different exon point mutations. RTK-RAS and TP53 pathways were the most affected pathways.
Source: Experimental Hematology and Oncology - Category: Cancer & Oncology Source Type: research