Associations of cardiovascular and diabetes-related risk factors with myocardial perfusion reserve assessed by 201Tl/99mTc-tetrofosmin single-photon emission computed tomography in patients with diabetes mellitus and stable coronary artery disease

AbstractWe aimed to examine the associations of cardiovascular risk factors with myocardial perfusion reserve (MPR) in patients with type 2 diabetes and stable coronary artery disease. The study patients were retrospectively identified from a database of patients with diabetes and stable coronary artery disease at Asan Medical Center (Seoul, Republic of Korea), covering the period from 2017 to 2019. The primary outcome variable was MPR assessed by dynamic stress201Tl/rest99mTc-tetrofosmin SPECT. Univariable and stepwise multivariable analyses were performed to assess the associations of cardiovascular risk factors with MPR. A total of 276 patients (236 men and 40 women) were included. The median global MPR was 2.4 (interquartile range 1.9 –3.0). Seventy-five (27.2%) patients had an MPR <  2.0. Multivariable linear regression showed that smoking (ß = − 0.44, 95% confidence interval − 0.68 to − 0.21,P <  0.001), hypertension (ß = − 0.24, 95% confidence interval − 0.47 to − 0.02,P = 0.033), and summed difference score (ß = − 0.05, 95% confidence interval − 0.07 to − 0.03,P <  0.001) were independently associated with MPR. Abnormal MPR (<  2.0) was associated with a higher incidence of cardiac death or myocardial infarction (P = 0.034). MPR assessed by dynamic stress201Tl/rest99mTc-tetrofosmin SPECT was impaired in a large cohort of patients with diabetes. After adjusting for risk variables, including stan...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research