Sex differences in Cardiorenal Syndrome: Insights from CARDIOREN Registry

This study aims to explore the sex-related differences in cardiorenal syndrome (CRS) in a contemporary cohort of outpatients with HF.FindingsAn analysis of the Cardiorenal Spanish registry (CARDIOREN) was performed. CARDIOREN Registry is a prospective multicenter observational registry including 1107 chronic ambulatory HF patients (37% females) from 13 Spanish HF clinics. Estimated Glomerular Filtration Rate (eGFR)  <  60 ml/min/1.73 m2 was present in 59.1% of the overall HF population, being this prevalence higher in the female population (63.2% vs. 56.6%,p = 0.032, median age: 81 years old, IQR:74–86). Among those with kidney dysfunction, women displayed higher odds of showing HF with preserved ejection fraction (HFpEF) (odds ratio [OR] = 4.07; confidence interval [CI] 95%: 2.65–6.25,p <  0.001), prior valvular heart disease (OR = 1.76; CI 95%:1.13–2.75,p = 0.014), anemia (OR: 2.02; CI 95%:1.30–3.14,p = 0.002), more advanced kidney disease (OR for CKD stage 3: 1.81; CI 95%:1.04–3.13,p = 0.034; OR for CKD stage 4: 2.49, CI 95%:1.31–4.70,p = 0.004) and clinical features of congestion (OR:1.51; CI 95%: 1.02–2.25, p = 0.039). On the contrary, males with cardiorenal disease showed higher odds of presenting HF with reduced ejection fraction (HFrEF) (OR:3.13; CI 95%: 1.90–5.16,p <  0.005), ischemic cardiomyopathy (OR:2.17; CI 95%: 1.31–3.61,p = 0.003), hypertension (OR = 2.11; CI 95%:1.18–3.78,p =...
Source: Current Heart Failure Reports - Category: Cardiology Source Type: research