Most Fractures Treated Nonoperatively in Individuals With Fibrodysplasia Ossificans Progressiva Heal With a Paucity of Flareups, Heterotopic Ossification, and Loss of Mobility

CONCLUSION: Most fractures treated nonoperatively in individuals with FOP healed with few flareups, little or no HO, and preservation of mobility, suggesting an uncoupling of fracture repair and HO, which are two inflammation-induced processes of endochondral ossification. These findings underscore the importance of considering nonoperative treatment for fractures in individuals with FOP. Physicians who treat fractures in patients with FOP should consult with a member of the International Clinical Council listed in the FOP Treatment Guidelines ( https://www.iccfop.org ).LEVEL OF EVIDENCE: Level IV, therapeutic study.PMID:37156007 | DOI:10.1097/CORR.0000000000002672

Source: Pain Physician - May 8, 2023 Category: Anesthesiology Authors: Carter M Lindborg Mona Al Mukaddam Genevieve Baujat Tae-Joon Cho Carmen L De Cunto Patricia L R Delai Elisabeth M W Eekhoff Nobuhiko Haga Edward C Hsiao Rolf Morhart Ruben de Ruiter Christiaan Scott Petra Seemann Ma łgorzata Szczepanek Jacek Tabarkiewicz Source Type: research