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Rare condition causes BONE to form in woman's muscles
Jasmin Floyd, from Connecticut, suffers with Fibrodysplasia Ossificans Progressiva - a rare muscle disorder which has only 800 recorded cases worldwide. (Source: the Mail online | Health)
Source: the Mail online | Health - March 16, 2017 Category: Consumer Health News Source Type: news

Wigan man turned stiff from ultra rare condition FOP dies
Adrian Berry, 40, from Wigan, suffered from fibrodysplasia ossificans progressiva. He passed away with pneumonia on Boxing Day (pictured with friends on his 40th birthday). (Source: the Mail online | Health)
Source: the Mail online | Health - January 19, 2017 Category: Consumer Health News Source Type: news

Her body is slowly growing a second skeleton
It's impossible for those who have fibrodysplasia ossificans progressiva, or FOP, to describe what it's like to live with it. (Source: CNN.com - Health)
Source: CNN.com - Health - December 26, 2016 Category: Consumer Health News Source Type: news

Quieting cells' low-oxygen alarm stops flare-ups in rare bone disorder
The cellular response to the lack of oxygen fans the flames of flare-ups in a rare bone disorder. In fibrodysplasia ossificans progressiva, a mutation triggers bone growth in muscles, which limits motion, breathing, and swallowing, among a host of progressive symptoms. The study identifies a therapeutic target for stopping the extra bone growth in FOP and other disorders. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 2, 2016 Category: Science Source Type: news

Drug candidate stops extra bone growth in animal model of rare, genetic disease
New preclinical research provides support to a drug that has been repurposed to possibly treat a rare and extremely disabling genetic bone disease, particularly in children. In that disease, fibrodysplasia ossificans progressiva (FOP), a mutation triggers bone growth in muscles, alters skeletal bone formation, and limits motion, breathing, and swallowing, among a host of progressive symptoms. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 13, 2016 Category: Science Source Type: news

Drug candidate halts crippling excess bone growth in animal model of a rare bone disease
(Children's Hospital of Philadelphia) New research in laboratory animals suggests that the drug palovarotene may prevent multiple skeletal problems caused by a rare but extremely disabling genetic bone disease, and may even be a candidate for use in newborn babies with the condition. Orthopedics researchers tested the drug candidate in mice carrying the human mutation that causes fibrodysplasia ossificans progressiva. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 13, 2016 Category: Global & Universal Source Type: news

Clementia completes patient enrolment in Phase II trial of palovarotene to treat FOP
Canada-based Clementia Pharmaceuticals has completed patient enrolment in its Phase II clinical trial of palovarotene, a retinoic acid receptor gamma agonist, to treat fibrodysplasia ossificans progressiva (FOP). (Source: Drug Development Technology)
Source: Drug Development Technology - March 1, 2016 Category: Pharmaceuticals Source Type: news

The teenager who's becoming a human statue: 17-year-old's muscles are turning to BONE due to bizarre incurable condition
Luciana Wulkan, 17, from Bolton, has Fibrodysplasia Ossificans Progressiva (FOP), one of the rarest and most disabling medical conditions, which turns muscle into solid bone. (Source: the Mail online | Health)
Source: the Mail online | Health - February 17, 2016 Category: Consumer Health News Source Type: news

Woman is desperate to conceive before genetic disease leaves her unable to move
Rachel Winnard, 31, from Rochdale, has Fibrodysplasia Ossificans Progressiva (FOP), one of the rarest and most disabling medical conditions, which turns muscle into solid bone. (Source: the Mail online | Health)
Source: the Mail online | Health - October 30, 2015 Category: Consumer Health News Source Type: news

Ashley Kurpiel has Fibrodysplasia Ossificans Progressiva that turns muscle into bone
Ashley Kurpiel, 32, Peachtree City, Georgia, has Fibrodysplasia Ossificans Progressiva (FOP), one of the rarest and most disabling medical conditions, which turns muscle into solid bone. (Source: the Mail online | Health)
Source: the Mail online | Health - October 22, 2015 Category: Consumer Health News Source Type: news

Clementia begins Phase II extension trial of palovarotene to treat FOP patients
Canada-based Clementia Pharmaceuticals has started a Phase II extension trial of palovarotene, an investigational retinoic acid receptor gamma agonist, to treat patients with fibrodysplasia ossificans progressiva (FOP), a rare and severely disabling … (Source: Drug Development Technology)
Source: Drug Development Technology - October 28, 2014 Category: Pharmaceuticals Source Type: news

The girl whose joints and muscles are turning to STONE: Horrific rare condition causes sufferers to become imprisoned in a second skeleton - which eventually suffocates them
Ni Min, 14, from China's Sichuan Province, suffers from the condition fibrodysplasia ossificans progressiva (FOP), also dubbed 'stone man' syndrome. (Source: the Mail online | Health)
Source: the Mail online | Health - September 25, 2014 Category: Consumer Health News Source Type: news

Clementia begins Phase II trial of palovarotene to treat fibrodysplasia ossificans progressiva
Canada-based Clementia Pharmaceuticals has started a double-blind, placebo-controlled Phase II clinical trial of palovarotene to treat fibrodysplasia ossificans progressiva (FOP), a rare, severely disabling genetic disease. (Source: Drug Development Technology)
Source: Drug Development Technology - July 14, 2014 Category: Pharmaceuticals Source Type: news

Stem cells used to model disease that causes abnormal bone growth (EurekAlert, 7 January 2014)
A US-Japan study published in the Orphanet Journal of Rare Diseases uses stem cells obtained from patients with the rare genetic condition fibrodysplasia ossificans progressiva to model abnormal bone growth, which the authors suggest could also model similar destructive processes occuring following major trauma. Full article (Source: Society for Endocrinology)
Source: Society for Endocrinology - January 9, 2014 Category: Endocrinology Source Type: news

[Erratum]A Correction to the Editors' Choice Summary Titled "Keeping Bone Where Bone Belongs" by Leslie K. Ferrarelli
Activating mutations in GNAS were mistakenly attributed as causing fibrodysplasia ossificans progressiva, instead of fibrous dysplasia. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 18, 2013 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

Girl, 17, battling rare disease that turns muscle into a second skeleton and will turn her into a living STATUE
Seanie Nammock, from West London, is suffering from fibrodysplasia ossificans progressiva (FOP), a condition that is turning her muscle and tendon into bone. (Source: the Mail online | Health)
Source: the Mail online | Health - July 29, 2013 Category: Consumer Health News Source Type: news