Cardiac sirtuin1 deficiency exacerbates ferroptosis in doxorubicin-induced cardiac injury through the Nrf2/Keap1 pathway

This study provides direct evidence that Sirt1 plays a protective role in DOX-induced cardiotoxicity by mediating ferroptosis reduction via the Nrf2/Keap1 pathway.PMID:37030624 | DOI:10.1016/j.cbi.2023.110469

Source: Chemico-Biological Interactions - April 8, 2023 Category: Molecular Biology Authors: Weiqi Wang Xin Zhong Zimin Fang Jianmin Li Hebo Li Xuesheng Liu Xindi Yuan Weijian Huang Zhouqing Huang Source Type: research