Current Landscape on Development of Phenylalanine and Toxicity of its Metabolites- A Review

Curr Drug Saf. 2023 Mar 31. doi: 10.2174/1574886318666230331112800. Online ahead of print.ABSTRACTPhenylalanine, an essential amino acid, is the "building block" of protein. It has a tremendous role in different aspects of metabolic events. The tyrosine pathway is the prime one and is typically used to degrade dietary phenylalanine. Phenylalanine exceeds its limit in bodily fluids and the brain when the enzyme, phenylalanine decarboxylase, phenylalanine transaminase, phenylalanine hydroxylase (PAH) or its cofactor tetrahydrobiopterin (BH4) is deficient causes phenylketonuria, schizophrenia, attention-deficit/hyperactivity disorder and another neuronal effect. Tyrosine, an amino acid necessary for synthesizing the pigments in melanin, is produced by its primary metabolic pathway. Deficiency/abnormality in metabolic enzymes responsible for the catabolism pathway of Phenylalanine causes an accumulation of the active intermediate metabolite, resulting in several abnormalities, such as developmental delay, tyrosinemias, alkaptonuria, albinism, hypotension and several other undesirable conditions. Dietary restriction of the amino acid(s) can be a therapeutic approach to avoid such undesirable conditions when the level of metabolic enzyme is unpredictable. After properly identifying the enzymatic level, specific pathophysiological conditions can be managed more efficiently.PMID:36999718 | DOI:10.2174/1574886318666230331112800

Source: Current Drug Safety - March 31, 2023 Category: Drugs & Pharmacology Authors: Samrat Bose Shirsendu Mandal Rajesh Khan Himangshu Sekhar Maji Sumel Ashique Source Type: research